A win-probability model fitted on historical play-by-play data can tell you what a 7-point lead with six minutes left is truly worth, and that number frequently differs from the live market, which overreacts to whatever just happened. You run the model against a live game-state feed and trade whenever the gap exceeds a threshold that covers fees. The hardest part is feed latency: if your data arrives later than everyone else's, you are the one being picked off.
Markets on Polymarket where live in-game win-probability divergence is the natural play: