Cancel out the directional crypto risk in Polymarket price-threshold markets by holding an offsetting spot or perpetual-futures position elsewhere (for example, short an ETH perp against a long 'ETH above $X' YES). This isolates the prediction-market mispricing from the coin's price moves. The edge is harvesting the spread between Polymarket's implied probability and the derivatives market's, without betting on whether the coin itself goes up or down.
Markets on Polymarket where on-chain delta hedge of crypto-price markets is the natural play: